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DNA sensing in senescence

Nature Cell Biology volume 19, pages 10081009 (2017) | Download Citation

  • An Erratum to this article was published on 29 November 2017

This article has been updated

Cellular senescence, a cell-autonomous growth arrest program, also executes pleiotropic non-cell-autonomous activities through the senescence-associated secretory phenotype (SASP). The innate cGAS–STING DNA-sensing pathway is now shown to regulate senescence by recognizing cytosolic DNA and inducing SASP factors, uncovering an unexpected link between these two previously unrelated pathways.

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Change history

  • 30 October 2017

    In the original version of this News and Views, the name of author Marina Ruiz de Galarreta was coded wrongly, resulting in it being incorrect when exported to citation databases. This has now been corrected, though no visible changes will be apparent.

References

  1. 1.

    & Nat. Rev. Mol. Cell Biol. 15, 482–496 (2014).

  2. 2.

    & Nat. Rev. Cancer 15, 397–408 (2015).

  3. 3.

    , , & J. Biol. Chem. 281, 29568–29574 (2006).

  4. 4.

    et al. Nat. Cell Biol. 15, 978–990 (2013).

  5. 5.

    et al. Nature 445, 656–660 (2007).

  6. 6.

    et al. Nat. Cell Biol. 19, 1061–1070 (2017).

  7. 7.

    , & Nat. Immunol. 17, 1142–1149 (2016).

  8. 8.

    et al. J. Cell Biol. 202, 129–143 (2013).

  9. 9.

    et al. Nat. Cell Biol. 11, 973–979 (2009).

  10. 10.

    et al. Science 349, aaa5612 (2015).

  11. 11.

    , , , & Proc. Natl Acad. Sci. USA 114, E4612–E4620 (2017).

  12. 12.

    et al. Cell 133, 1019–1031 (2008).

  13. 13.

    et al. Nature 479, 547–551 (2011).

  14. 14.

    et al. Proc. Natl Acad. Sci. USA 114, 1637–1642 (2017).

  15. 15.

    et al. Nature 436, 642 (2005).

Download references

Author information

Affiliations

  1. Marina Ruiz de Galarreta and Amaia Lujambio are in the Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York 10029, USA and at the Liver Cancer Program, Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York 10029, USA

    • Marina Ruiz de Galarreta
    •  & Amaia Lujambio
  2. Amaia Lujambio is also at the Graduate School of Biomedical Sciences at Icahn School of Medicine at Mount Sinai, New York 10029, USA

    • Amaia Lujambio

Authors

  1. Search for Marina Ruiz de Galarreta in:

  2. Search for Amaia Lujambio in:

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Amaia Lujambio.

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DOI

https://doi.org/10.1038/ncb3603

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