A fruitful liaison of ZSCAN10 and ROS on the road to rejuvenation

Induced pluripotent stem cells derived from aged donors (A-iPSCs) usually show genomic instability that affects their utility and raises concerns about their safety. Now, a study highlights the importance of ZSCAN10-dependent recovery of glutathione–ROS homeostasis in counteracting the genomic defects in A-iPSCs.

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Figure 1: ZSCAN10 preserves genomic stability in iPSCs through the maintenance of ROS levels.

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Correspondence to Carlos López-Otín.

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Bárcena, C., López-Otín, C. A fruitful liaison of ZSCAN10 and ROS on the road to rejuvenation. Nat Cell Biol 19, 1012–1013 (2017). https://doi.org/10.1038/ncb3602

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