Supplementary Figure 3 : Mitotic chromosome compaction requires cohesin function.

From: SMC complexes differentially compact mitotic chromosomes according to genomic context

Supplementary Figure 3

(a) (Top) Zoom into contact heatmaps from MH data for selected regions on (left) ChrXV (0-330 kb (CENXV is at 330 kb)) and (right) the post-rDNA region of ChrXII (660 kb to 940 kb). (Bottom) Zoom into log2 ratio of MH over M contact maps for selected regions on (left) ChrXV (0-330 kb (CENXV is at 330 kb)) and (right) the post-rDNA region of ChrXII (660 kb to 940 kb). (b) (Left) Log2 (MH/M) ratio of contacts for ChrXII. Regions where contact frequency was higher in MH (-cohesin) than M (wt cohesin) are shown in red, regions where contact frequency was lower in MH than M in blue. The post-rDNA region is highlighted by the orange bar. (Right) Contact probability, P(s), as a function of genomic separation, s, specifically for the post-rDNA region of ChrXII for the replicate experiments of MH and M. All contact maps shown were assembled from two independent experiments.