Supplementary Figure 2 : Mitotic chromosome conformation can be accounted for by addition of intra-chromosomal loops, but not by sister-crosslinks.

From: SMC complexes differentially compact mitotic chromosomes according to genomic context

Supplementary Figure 2

(a) The family of P(s) curves for 150 loops, and a range of different coverage levels (left). And the family of P(s) curves for coverage = 0.4, and a range of number of loops (right). (b) Simulations with sister-crosslinks imposed with the indicated frequency (12 kb, 192 kb, none) at random positions along chromosome arms in different simulations. Importantly, sister-crosslink simulations do not display two phases in their P(s), unlike experimental M-phase P(s) curves (grey, two replicas).