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Enhancing brown fat with NFIA

Nature Cell Biology volume 19, pages 10061007 (2017) | Download Citation

Brown adipose tissue is a key metabolic organ that oxidizes fatty acids and glucose to generate heat. Through epigenomic analyses of multiple adipose depots, the transcription factor nuclear factor I-A (NFIA) is now shown to drive the brown fat genetic program through binding to lineage-specific cis-regulatory elements.

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Author information

Affiliations

  1. Suzanne N. Shapira and Patrick Seale are at the Institute for Diabetes, Obesity, and Metabolism, Department of Cell and Developmental Biology, Smilow Center for Translational Research, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA

    • Suzanne N. Shapira
    •  & Patrick Seale

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Patrick Seale.

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DOI

https://doi.org/10.1038/ncb3591

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