Brown adipose tissue is a key metabolic organ that oxidizes fatty acids and glucose to generate heat. Through epigenomic analyses of multiple adipose depots, the transcription factor nuclear factor I-A (NFIA) is now shown to drive the brown fat genetic program through binding to lineage-specific cis-regulatory elements.
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Shapira, S., Seale, P. Enhancing brown fat with NFIA. Nat Cell Biol 19, 1006–1007 (2017). https://doi.org/10.1038/ncb3591
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DOI: https://doi.org/10.1038/ncb3591