Origin and regulation of a lung repair kit

The lung undergoes a striking repair process in response to severe injuries such as influenza infection. A study now demonstrates that associated stem/progenitor cells are heterogeneous in nature and comprise subpopulations dominated by hypoxia/Notch or Wnt signalling. Modulation of this heterogeneity in favour of functional repair may have therapeutic value.

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Figure 1: Severe lung injury such as influenza infection causes widespread epithelial cell death (grey dashed lines), which might be repaired by rare small airway p63+ cells (red), p63 cells (blue), or more conventional cells (green).

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Correspondence to Jichao Chen.

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Chen, J. Origin and regulation of a lung repair kit. Nat Cell Biol 19, 885–886 (2017). https://doi.org/10.1038/ncb3585

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