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CTCF fences make good neighbours

Nature Cell Biology volume 19, pages 883–885 (2017)Cite this article

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CCCTC-binding factor (CTCF) sites are enriched at the boundaries of topologically associated domains (TADs), but their function within TADs is unclear. Removal of sub-TAD CTCF sites adjacent to the α-globin enhancers is now shown to result in inappropriate activation of neighbouring genes. Intra-TAD enhancer insulation might be broadly important for tissue specificity of enhancers.

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Figure 1: The α-globin cluster in mouse ESCs and primary erythroid cells.

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  1. Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, 20892, Maryland, USA

    Ivan Krivega & Ann Dean

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  1. Ivan Krivega
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  2. Ann Dean
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Correspondence to Ann Dean.

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The authors declare no competing financial interests.

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Krivega, I., Dean, A. CTCF fences make good neighbours. Nat Cell Biol 19, 883–885 (2017). https://doi.org/10.1038/ncb3584

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