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Lgr5 joins the club of gastric stem cell markers in the corpus

Nature Cell Biology volume 19, pages 752754 (2017) | Download Citation

Several markers of gastric stem cells have been identified in recent years. Now a study demonstrates that Lgr5 marks a population of reserve stem cells located at the base of the corpus glands of the gastric epithelium, and that these cells can also act as a cell-of-origin for gastric tumorigenesis.

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Author information

Affiliations

  1. Toby J. Phesse is at the European Cancer Stem Cell Research Institute, Cardiff University, Cardiff CF24 4HQ, UK

    • Toby J. Phesse
  2. Owen J. Sansom is at the Cancer Research UK Beatson Institute, Garscube Estate, Bearsden, Glasgow G61 1BD, UK and at the Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1BD, UK

    • Owen J. Sansom

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Competing interests

The authors declare no competing financial interests.

Corresponding authors

Correspondence to Toby J. Phesse or Owen J. Sansom.

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DOI

https://doi.org/10.1038/ncb3567

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