Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

OPA1 and cardiolipin team up for mitochondrial fusion

Fusion between the inner membranes of two mitochondria requires the GTPase optic atrophy 1 (OPA1), but the molecular mechanism is poorly understood. A study now shows that fusion of two liposomes can be performed by OPA1 tethered to just one liposome, through an interaction with the phospholipid cardiolipin on the opposing liposome.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: L-OPA1 and cardiolipin interactions mediate membrane fusion.

References

  1. 1

    Chan, D. C. Annu. Rev. Genet. 46, 265–287 (2012).

    CAS  Article  Google Scholar 

  2. 2

    Ban, T. et al. Nat. Cell Biol. http://dx.doi.org/10.1038/ncb3560 (2017).

  3. 3

    Koshiba, T. et al. Science 305, 858–862 (2004).

    CAS  Article  Google Scholar 

  4. 4

    Cao, Y. L. et al. Nature 542, 372–376 (2017).

    CAS  Article  Google Scholar 

  5. 5

    Qi, Y. et al. J. Cell Biol. 215, 621–629 (2016).

    CAS  Article  Google Scholar 

  6. 6

    Orso, G. et al. Nature 460, 978–983 (2009).

    CAS  Article  Google Scholar 

  7. 7

    Song, Z., Ghochani, M., McCaffery, J. M., Frey, T. G. & Chan, D. C. Mol. Biol. Cell 20, 3525–3532 (2009).

    CAS  Article  Google Scholar 

  8. 8

    Mishra, P., Carelli, V., Manfredi, G. & Chan, D. C. Cell Metab. 19, 630–641 (2014).

    CAS  Article  Google Scholar 

  9. 9

    Song, Z., Chen, H., Fiket, M., Alexander, C. & Chan, D. C. J. Cell Biol. 178, 749–755 (2007).

    CAS  Article  Google Scholar 

  10. 10

    Tondera, D. et al. EMBO J. 28, 1589–1600 (2009).

    CAS  Article  Google Scholar 

  11. 11

    Anand, R. et al. J. Cell Biol. 204, 919–929 (2014).

    CAS  Article  Google Scholar 

  12. 12

    Frezza, C. et al. Cell 126, 177–189 (2006).

    CAS  Article  Google Scholar 

  13. 13

    DeVay, R. M. et al. J. Cell Biol. 186, 793–803 (2009).

    CAS  Article  Google Scholar 

  14. 14

    Zick, M. et al. FEBS Lett. 583, 2237–2243 (2009).

    CAS  Article  Google Scholar 

  15. 15

    Ban, T., Heymann, J. A., Song, Z., Hinshaw, J. E. & Chan, D. C. Hum. Mol. Genet. 19, 2113–2122 (2010).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to David C. Chan.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Liu, R., Chan, D. OPA1 and cardiolipin team up for mitochondrial fusion. Nat Cell Biol 19, 760–762 (2017). https://doi.org/10.1038/ncb3565

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing