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OPA1 and cardiolipin team up for mitochondrial fusion

Fusion between the inner membranes of two mitochondria requires the GTPase optic atrophy 1 (OPA1), but the molecular mechanism is poorly understood. A study now shows that fusion of two liposomes can be performed by OPA1 tethered to just one liposome, through an interaction with the phospholipid cardiolipin on the opposing liposome.

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Figure 1: L-OPA1 and cardiolipin interactions mediate membrane fusion.


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Correspondence to David C. Chan.

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Liu, R., Chan, D. OPA1 and cardiolipin team up for mitochondrial fusion. Nat Cell Biol 19, 760–762 (2017).

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