Reducing interferon'ce in stem cells

Little is known regarding how the interactions of stem cells with the immune system regulate their plasticity. A study now describes a mechanism by which normal breast and cancer stem cells utilize miR-199a to downregulate the corepressor LCOR and minimize responses to type I interferon.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Regulation of stemness by controlling cellular responses to type I IFNs through the miR-199a–LCOR axis.

References

  1. 1

    Visvader, J. E. & Clevers, H. Nat. Cell Biol. 18, 349–355 (2016).

  2. 2

    Visvader, J. E. & Stingl, J. Genes Dev. 28, 1143–1158 (2014).

  3. 3

    Shenoy, A. & Blelloch, R. H. Nat. Rev. Mol. Cell Biol. 15, 565–576 (2014).

  4. 4

    Gangaraju, V. K. & Lin, H. Nat. Rev. Mol. Cell Biol. 10, 116–125 (2009).

  5. 5

    Aurora, A. B. & Olson, E. N. Cell Stem Cell 15, 14–25 (2014).

  6. 6

    Celià-Terrassa, T. et al. Nat. Cell Biol. 19, 711–723 (2017).

  7. 7

    O'Brien, J. et al. Am. J. Pathol. 176, 1241–1255 (2010).

  8. 8

    Cheng, W., Liu, T., Wan, X., Gao, Y. & Wang, H. FEBS J. 279, 2047–2059 (2012).

  9. 9

    Liu, R. et al. Oncotarget 7, 56628–56642 (2016).

  10. 10

    Hu, Y. et al. Dig. Dis. Sci. 59, 2163–2172 (2014).

  11. 11

    Zitvogel, L., Galluzzi, L., Kepp, O., Smyth, M. J. & Kroemer, G. Nat. Rev. Immunol. 15, 405–414 (2015).

  12. 12

    Chen, H. M. et al. Cancer Sci. 100, 449–456 (2009).

  13. 13

    Maccalli, C., Volontè, A., Cimminiello, C. & Parmiani, G. Eur. J. Cancer 50, 649–655 (2014).

Download references

Author information

Correspondence to Brian Ruffell.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Gardner, A., Ruffell, B. Reducing interferon'ce in stem cells. Nat Cell Biol 19, 597–599 (2017). https://doi.org/10.1038/ncb3544

Download citation