Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Mitochondria link metabolism and epigenetics in haematopoiesis

Nature Cell Biology volume 19, pages 589–591 (2017)Cite this article

Subjects

Due to their varied metabolic and signalling roles, mitochondria are important in mediating cell behaviour. By altering mitochondrial function, two studies now identify metabolite-induced epigenetic changes that have profound effects on haematopoietic stem cell fate and function.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Mitochondrial regulation of haematopoiesis.

References

  1. Ito, K. & Suda, T. Nat. Rev. Mol. Cell Biol. 15, 243–256 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Figueroa, M. E. et al. Cancer Cell 18, 553–567 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Xiao, M. et al. Genes Dev. 26, 1326–1338 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Birsoy, K. et al. Cell 162, 540–551 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Sullivan, L. B. et al. Cell 162, 552–563 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Chandel, N. S. Cell Metab. 22, 204–206 (2015).

    Article  CAS  PubMed  Google Scholar 

  7. Liu, X. et al. Nat. Cell Biol. 19, 626–638 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Ansó, E. et al. Nat. Cell Biol. 19, 614–625 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Spangrude, G. J., Heimfeld, S. & Weissman, I. L. Science 241, 58–62 (1988).

    Article  CAS  PubMed  Google Scholar 

  10. Morita, M. et al. Cell Metab. 18, 698–711 (2013).

    Article  CAS  PubMed  Google Scholar 

  11. Lezza, A. M. S. Front. Biol. 7, 30–39 (2012).

    Article  CAS  Google Scholar 

  12. Lu, C. & Thompson, C. B. Cell Metab. 16, 9–17 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Mullen, A. R. et al. Cell Rep. 7, 1679–1690 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Martínez-Reyes, I. et al. Mol. Cell 61, 199–209 (2016).

    Article  PubMed  Google Scholar 

  15. Xu, W. et al. Cancer Cell 19, 17–30 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry and Howard Hughes Medical Institute, University of Utah School of Medicine, 15 North Medical Drive East, Room 5520A, Salt Lake City, 84112-5650, Utah, USA

    John C. Schell & Jared Rutter

Authors
  1. John C. Schell
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jared Rutter
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jared Rutter.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Schell, J., Rutter, J. Mitochondria link metabolism and epigenetics in haematopoiesis. Nat Cell Biol 19, 589–591 (2017). https://doi.org/10.1038/ncb3540

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb3540

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing