Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Metabolic changes promote rejection of oncogenic cells

Nature Cell Biology volume 19, pages 414–415 (2017)Cite this article

Subjects

Dysfunctional cells are eliminated from epithelial monolayers by a process known as cell extrusion to maintain tissue homeostasis. Normal epithelial cells are now shown to induce the extrusion of oncogene-transformed cells by inducing metabolic changes in the oncogene-expressing cells through PDK4-mediated inhibition of PDH and mitochondrial metabolism.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The reciprocal relationship between ECM interaction and PDK4-induced metabolic changes, and the potential fates of apically extruded transformed cells.

References

  1. Gudipaty, S. A. & Rosenblatt, J. Semin. Cell Dev. Biol. (in the press).

  2. Di Gregorio, A., Bowling, S. & Rodriguez, T. A. Dev. Cell 38, 621–634 (2016).

    Article  CAS  PubMed  Google Scholar 

  3. Hogan, C. et al. Nat. Cell Biol. 11, 460–467 (2009).

    Article  CAS  PubMed  Google Scholar 

  4. Kajita, M. et al. Nat. Commun. 5, 4428 (2014).

    Article  CAS  PubMed  Google Scholar 

  5. Ohoka, A. et al. J. Cell Sci. 128, 781–789 (2015).

    Article  CAS  PubMed  Google Scholar 

  6. Kon, S. et al. Nat. Cell Biol. 19, 530–541 (2017).

    Article  CAS  PubMed  Google Scholar 

  7. Warburg, O., Wind, F. & Negelein, E. J. Gen. Physiol. 8, 519–530 (1927).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Grassian, A. R., Metallo, C. M., Coloff, J. L., Stephanopoulos, G. & Brugge, J. S. Genes Dev. 25, 1716–1733 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Grassian, A. R., Coloff, J. L. & Brugge, J. S. Cold Spring Harb. Symp. Quant. Biol. 76, 313–324 (2011).

    Article  CAS  PubMed  Google Scholar 

  10. Schafer, Z. T. et al. Nature 461, 109–113 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Jiang, L. et al. Nature 532, 255–258 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Kamarajugadda, S. et al. Mol. Cell. Biol. 32, 1893–1907 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Leung, C. T. & Brugge, J. S. Nature 482, 410–413 (2012).

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Marshall, T. W., Lloyd, I. E., Delalande, J. M., Nathke, I. & Rosenblatt, J. Mol. Biol. Cell 22, 3962–3970 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Slattum, G., Gu, Y., Sabbadini, R. & Rosenblatt, J. Curr. Biol. 24, 19–28 (2014).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Jonathan L. Coloff and Joan S. Brugge are in the Department of Cell Biology, Ludwig Center at Harvard, Harvard Medical School, Boston, Massachussetts, USA,

    Jonathan L. Coloff & Joan S. Brugge

Authors
  1. Jonathan L. Coloff
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Joan S. Brugge
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Joan S. Brugge.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Coloff, J., Brugge, J. Metabolic changes promote rejection of oncogenic cells. Nat Cell Biol 19, 414–415 (2017). https://doi.org/10.1038/ncb3521

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb3521

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer