Dysfunctional cells are eliminated from epithelial monolayers by a process known as cell extrusion to maintain tissue homeostasis. Normal epithelial cells are now shown to induce the extrusion of oncogene-transformed cells by inducing metabolic changes in the oncogene-expressing cells through PDK4-mediated inhibition of PDH and mitochondrial metabolism.
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Coloff, J., Brugge, J. Metabolic changes promote rejection of oncogenic cells. Nat Cell Biol 19, 414–415 (2017). https://doi.org/10.1038/ncb3521
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