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Context-specific roles of EMT programmes in cancer cell dissemination

The role of the epithelial-to-mesenchymal transition in tumour progression remains a topic of intense debate. Now, data on the role of Zeb1 in the metastatic spread of pancreatic cancer clarify apparently conflicting views by revealing context-specific, differential use of individual epithelial-to-mesenchymal transition transcription factors in cancer cell dissemination.

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Figure 1: Roles of EMT in cancer cell dissemination and progression.

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Correspondence to M. Angela Nieto.

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Nieto, M. Context-specific roles of EMT programmes in cancer cell dissemination. Nat Cell Biol 19, 416–418 (2017). https://doi.org/10.1038/ncb3520

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