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PARL paves the way to apoptosis

Although the mitochondrial inner membrane rhomboid peptidase PARL is known to participate in critical signalling cascades, its role in apoptosis has remained unclear. PARL is now shown to process the mitochondrial pro-apoptotic protein Smac (also known as DIABLO) for its subsequent release into the cytosol where it antagonizes XIAP-mediated caspase inhibition to promote apoptosis.

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Figure 1: Independent pathways ensure the release of pro-apoptotic proteins from mitochondria.


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Correspondence to Katsuyoshi Mihara.

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Ishihara, N., Mihara, K. PARL paves the way to apoptosis. Nat Cell Biol 19, 263–265 (2017).

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