Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

PARL paves the way to apoptosis

Although the mitochondrial inner membrane rhomboid peptidase PARL is known to participate in critical signalling cascades, its role in apoptosis has remained unclear. PARL is now shown to process the mitochondrial pro-apoptotic protein Smac (also known as DIABLO) for its subsequent release into the cytosol where it antagonizes XIAP-mediated caspase inhibition to promote apoptosis.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Independent pathways ensure the release of pro-apoptotic proteins from mitochondria.

References

  1. 1

    Friedman, J. R. & Nunnari, J. Nature 505, 335–343 (2014).

    CAS  Article  Google Scholar 

  2. 2

    Pernas, L. & Scorrano, L. Annu. Rev. Physiol. 78, 505–531 (2016).

    CAS  Article  Google Scholar 

  3. 3

    Mishra, P. & Chan, D. C. J. Cell Biol. 212, 379–387 (2016).

    CAS  Article  Google Scholar 

  4. 4

    Saita, S. et al. Nat. Cell Biol. 19, 318–328 (2017).

    CAS  Article  Google Scholar 

  5. 5

    Lee, J. E., Westrate, L. M., Wu, H., Page, C. & Voeltz, G. K. Nature 540, 139–143 (2016).

    CAS  Article  Google Scholar 

  6. 6

    Otera, H., Miyata, N., Kuge, O. & Mihara, K. J. Cell Biol. 212, 531–544 (2016).

    CAS  Article  Google Scholar 

  7. 7

    Glytsou, C. et al. Cell Rep. 17, 3024–3034 (2016).

    CAS  Article  Google Scholar 

  8. 8

    Jin, S. M. et al. J. Cell Biol. 191, 933–942 (2010).

    CAS  Article  Google Scholar 

  9. 9

    Sekine, S. et al. J. Biol. Chem. 287, 34635–34645 (2012).

    CAS  Article  Google Scholar 

  10. 10

    Narendra, D. P. et al. PLoS Biol. 8, e1000298 (2010).

    Article  Google Scholar 

  11. 11

    Cipolat, S. et al. Cell 126, 163–175 (2006).

    CAS  Article  Google Scholar 

  12. 12

    Griparic, L., Kanazawa, T. & van der Bliek, A. M. J. Cell Biol. 178, 757–764 (2007).

    CAS  Article  Google Scholar 

  13. 13

    Ghezzi, D. et al. Nat. Genet. 43, 259–263 (2011).

    CAS  Article  Google Scholar 

  14. 14

    Saunders, C. et al. Am. J. Hum. Genet. 96, 258–265 (2015).

    CAS  Article  Google Scholar 

  15. 15

    Yang, L. et al. J. Immunol. 194, 5635–5643 (2015).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Katsuyoshi Mihara.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Ishihara, N., Mihara, K. PARL paves the way to apoptosis. Nat Cell Biol 19, 263–265 (2017). https://doi.org/10.1038/ncb3504

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing