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Talin gets SHANKed in the fight for integrin activation

Genetic mutations in the SHANK family of proteins are linked to multiple neuropsychiatric disorders including autism spectrum disorders. A study now elucidates critical roles for SHANK in regulating integrin-mediated cell–extracellular matrix adhesion, by sequestering integrin activators.

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Figure 1: Shank suppresses talin-mediated integrin activation and adhesion formation.


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Correspondence to Christoph Ballestrem.

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Atherton, P., Ballestrem, C. Talin gets SHANKed in the fight for integrin activation. Nat Cell Biol 19, 265–267 (2017).

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