Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Lnc-ing ROR1–HER3 and Hippo signalling in metastasis

Long noncoding RNAs (lncRNAs) are increasingly recognized for their role in cancer progression. The previously uncharacterized lncRNA MAYA is now shown to promote bone metastasis by bridging ROR1–HER3 and Hippo–YAP pathways. Neuregulin-induced HER3 phosphorylation by ROR1 recruits a MAYA-containing protein complex to methylate Hippo/MST1 and activate YAP target genes that are essential for bone metastasis.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The lncRNA MAYA mediates the cross-talk between the ROR1–HER3 and Hippo pathways to promote bone metastasis.


  1. Weilbaecher, K. N., Guise, T. A. & McCauley, L. K. Nat. Rev. Cancer 11, 411–425 (2011).

    Article  CAS  Google Scholar 

  2. Moroishi, T., Hansen, C. G. & Guan, K. L. Nat. Rev. Cancer 15, 73–79 (2015).

    Article  CAS  Google Scholar 

  3. Chen, D. et al. Nat. Med. 18, 1511–1517 (2012).

    Article  CAS  Google Scholar 

  4. Shimo, T. et al. J. Bone Miner. Res. 21, 1045–1059 (2006).

    Article  CAS  Google Scholar 

  5. Attisano, L. & Wrana, J. L. F1000Prime Rep. 5, 17 (2013).

    Article  Google Scholar 

  6. Fan, R., Kim, N.-G. & Gumbiner, B. M. Proc. Natl Acad. Sci. USA 110, 2569–2574 (2013).

    Article  CAS  Google Scholar 

  7. Arteaga, C. L. & Engelman, J. A. Cancer Cell 25, 282–303 (2014).

    Article  CAS  Google Scholar 

  8. Sergina, N. V. et al. Nature 445, 437–441 (2007).

    Article  CAS  Google Scholar 

  9. Li, C. et al. Nat. Cell Biol. 19, 106–119 (2017).

    Article  CAS  Google Scholar 

  10. Borcherding, N., Kusner, D., Liu, G.-H. & Zhang, W. Protein Cell 5, 496–502 (2014).

    Article  CAS  Google Scholar 

  11. Johnson, R. & Halder, G. Nat. Rev. Drug Discov. 13, 63–79 (2014).

    Article  CAS  Google Scholar 

  12. Geisler, S. & Coller, J. Nat. Rev. Mol. Cell Biol. 14, 699–712 (2013).

    Article  CAS  Google Scholar 

  13. Wang, P. et al. Science 344, 310–313 (2014).

    Article  CAS  Google Scholar 

  14. Liu, B. et al. Cancer Cell 27, 370–381 (2015).

    Article  CAS  Google Scholar 

  15. Denkert, C., Liedtke, C., Tutt, A. & von Minckwitz, G. Lancet (2016).

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Yibin Kang.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhuo, W., Kang, Y. Lnc-ing ROR1–HER3 and Hippo signalling in metastasis. Nat Cell Biol 19, 81–83 (2017).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer