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Getting a grip on collective cell migration

Many cell types in our body move in a collective manner, which requires individual cells to align their movements relative to that of their neighbours. A mechanism is now described in which cadherin-rich protrusions are extended from leading migrating cells and engulfed by follower cells to guide collective migration.

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Figure 1: The emergence of VE-cadherin fingers from the rear end of leader cells and their engulfment at the front end of the immediate follower cells guides the two-dimensional collective migration of HUVECs in vitro.

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Correspondence to Tamal Das or Joachim P. Spatz.

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Das, T., Spatz, J. Getting a grip on collective cell migration. Nat Cell Biol 18, 1265–1267 (2016). https://doi.org/10.1038/ncb3447

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