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IQGAP1 makes PI(3)K signalling as easy as PIP, PIP2, PIP3

Despite being one of the most studied signalling pathways, precisely how phospholipid synthesis is regulated in the phosphoinositide signalling cascade remains unclear. The scaffold protein IQGAP1 is now shown to orchestrate the assembly of a multi-enzyme complex that streamlines PtdIns(3,4,5)P3 synthesis to facilitate Akt activation in response to extracellular stimuli.

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Figure 1: A diagram depicting two modalities of phosphoinositide signalling; a processive mode and a non-processive mode.

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Correspondence to Lucia E. Rameh.

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Rameh, L., Mackey, A. IQGAP1 makes PI(3)K signalling as easy as PIP, PIP2, PIP3. Nat Cell Biol 18, 1263–1265 (2016). https://doi.org/10.1038/ncb3440

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