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A new bookmark of the mitotic genome in embryonic stem cells

Embryonic stem cells maintain pluripotency through countless mitoses. A recent report shows that the transcription factor Esrrb remains bound to chromatin during mitosis, including at regulatory regions that support pluripotency. Mitotic chromatin occupancy by Esrrb might stabilize the defining transcriptional programmes of embryonic stem cells through cell division.

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Figure 1: Partial retention of Esrrb on mitotic chromatin.

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Correspondence to Gerd A. Blobel.

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Hsiung, CS., Blobel, G. A new bookmark of the mitotic genome in embryonic stem cells. Nat Cell Biol 18, 1124–1125 (2016). https://doi.org/10.1038/ncb3432

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