Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

A new bookmark of the mitotic genome in embryonic stem cells

Embryonic stem cells maintain pluripotency through countless mitoses. A recent report shows that the transcription factor Esrrb remains bound to chromatin during mitosis, including at regulatory regions that support pluripotency. Mitotic chromatin occupancy by Esrrb might stabilize the defining transcriptional programmes of embryonic stem cells through cell division.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Partial retention of Esrrb on mitotic chromatin.


  1. 1

    Kadauke, S. & Blobel, G. A. Epigenetics Chromatin 6, 6 (2013).

    CAS  Article  Google Scholar 

  2. 2

    Martínez-Balbás, M. A., Dey, A., Rabindran, S. K., Ozato, K. & Wu, C. Cell 83, 29–38 (1995).

    Article  Google Scholar 

  3. 3

    Hsiung, C. C. et al. Genome Res. 25, 213–225 (2015).

    CAS  Article  Google Scholar 

  4. 4

    Wang, F. & Higgins, J. M. G. Trends Cell Biol. 23, 175–184 (2013).

    CAS  Article  Google Scholar 

  5. 5

    Kadauke, S. et al. Cell 150, 725–737 (2012).

    CAS  Article  Google Scholar 

  6. 6

    Caravaca, J. M. et al. Genes Dev. 27, 251–260 (2013).

    CAS  Article  Google Scholar 

  7. 7

    Festuccia, N. et al. Nat. Cell Biol. 18, 1139–1148 (2016).

    CAS  Article  Google Scholar 

  8. 8

    Martello, G. et al. Cell Stem Cell 11, 491–504 (2012).

    CAS  Article  Google Scholar 

  9. 9

    Festuccia, N. et al. Cell Stem Cell 11, 477–490 (2012).

    CAS  Article  Google Scholar 

  10. 10

    Chen, D. et al. J. Cell Biol. 168, 41–54 (2005).

    CAS  Article  Google Scholar 

  11. 11

    Lake, R. J., Tsai, P.-F., Choi, I., Won, K.-J. & Fan, H.-Y. PLoS Genet. 10, e1004204 (2014).

    Article  Google Scholar 

  12. 12

    Follmer, N. E., Wani, A. H. & Francis, N. J. PLoS Genet. 8, e1003135 (2012).

    CAS  Article  Google Scholar 

  13. 13

    Yang, J., Sung, E., Donlin-Asp, P. G. & Corces, V. G. Nat. Commun. 4, 1464 (2013).

    Article  Google Scholar 

  14. 14

    Dalton, S. Trends Cell Biol. 25, 592–600 (2015).

    Article  Google Scholar 

  15. 15

    Hsiung, C. C. et al. Genes Dev. 30, 1423–1439 (2016).

    CAS  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Gerd A. Blobel.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Hsiung, CS., Blobel, G. A new bookmark of the mitotic genome in embryonic stem cells. Nat Cell Biol 18, 1124–1125 (2016).

Download citation


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing