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On keeping the right ER size

The endoplasmic reticulum (ER) is the largest membrane-bound organelle in cells, and its size needs to be carefully controlled. Downsizing the ER by autophagy is now shown to involve Sec62, a protein that also helps to build up the organelle. This link suggests a molecular switch for ER size control.

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Figure 1: Sec62 coordinates ER biogenesis and degradation.


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Correspondence to Sebastian Schuck.

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Schuck, S. On keeping the right ER size. Nat Cell Biol 18, 1118–1119 (2016).

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