Nature Cell Biology 18, 467–479 (2016); published online 18 April 2016; corrected after print 27 September 2016

In the version of this Article originally published, the authors inadvertently omitted a key reference. The following reference has been added: '48. Rocha, A. S. et al. The angiocrine factor Rspondin3 is a key determinant of liver zonation. Cell Rep. 13, 1757–1764 (2015).' References 48–56 have been renumbered accordingly. Furthermore, a new sentence citing this reference has been added at the end of the first paragraph in the Discussion: 'A recent report that was published during the final revision of our manuscript suggests a role for pericentrally confined RSPO3 in metabolic liver zonation48.' These changes have been made in the online versions of the Article.