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Melanosomes foster a tumour niche by activating CAFs

Nature Cell Biology volume 18, pages 911–913 (2016)Cite this article

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Extracellular vesicles, such as exosomes, are important effectors in the formation of tumour-fostering niches. Pigmented melanosomes are now shown to have a relevant role in establishing a tumour niche in primary melanoma by reprogramming dermal fibroblasts into cancer-associated fibroblasts through the transfer of miR-211.

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Figure 1: Melanosomes mediate transformation of dermal fibroblasts into CAFs, favouring tumorigenesis.

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Authors and Affiliations

  1. Susana García-Silva and Héctor Peinado are in the Microenvironment and Metastasis Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain,

    Susana García-Silva & Héctor Peinado

  2. Héctor Peinado is also in the Department of Pediatrics, Drukier Institute for Children's Health and Meyer Cancer Center, Weill Cornell Medical College, New York, 10021 New York, USA,

    Héctor Peinado

Authors
  1. Susana García-Silva
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  2. Héctor Peinado
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Correspondence to Héctor Peinado.

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García-Silva, S., Peinado, H. Melanosomes foster a tumour niche by activating CAFs. Nat Cell Biol 18, 911–913 (2016). https://doi.org/10.1038/ncb3404

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