Mapping the molecular steps of secretory-lysosome-driven tracheal tube fusion

During development, tubular networks form through the joining of lumenized branches. Further insights into tracheal tube fusion in Drosophila melanogaster now reveal the molecular steps that promote the connection of two apical membrane compartments within a single cell through secretory lysosomes.

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Figure 1: Lumen formation in the tracheal system of wild-type and staccato mutant Drosophila embryos.

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Correspondence to Markus Affolter.

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Aydogan, V., Belting, H. & Affolter, M. Mapping the molecular steps of secretory-lysosome-driven tracheal tube fusion. Nat Cell Biol 18, 720–722 (2016). https://doi.org/10.1038/ncb3383

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