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p21 shapes cancer evolution

Although known to induce cellular senescence, an important tumour suppressor mechanism, mutation of CDKN1A — the gene encoding p21 (also known as WAF1 or CIP1) — is rare in human cancers. Now, a study reports a previously unappreciated oncogenic effect of p21 overexpression that shapes cancer genome evolution through induction of replication stress.

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Figure 1: p21 regulates various cellular programs by different mechanisms.
Figure 2: The model proposed by Galanos et al.

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Correspondence to K. Lenhard Rudolph.

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Romanov, V., Rudolph, K. p21 shapes cancer evolution. Nat Cell Biol 18, 722–724 (2016). https://doi.org/10.1038/ncb3382

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