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New MAPS for misfolded proteins

Clearing misfolded proteins from the cytoplasm is essential to maintain cellular homeostasis. Now, a parallel clearance system is described that uses the deubiquitylase USP19 to enable secretion of misfolded cytoplasmic proteins when conventional proteasomal degradation is compromised. Misfolding-associated protein secretion (MAPS) has important implications for protein quality control and prion-like transmission.

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Figure 1: Clearance of misfolded cytoplasmic proteins via the MAPS pathway.


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N.V. and E.F. contributed equally to this work.

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Correspondence to John C. Christianson.

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The authors declare no competing financial interests.

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Volkmar, N., Fenech, E. & Christianson, J. New MAPS for misfolded proteins. Nat Cell Biol 18, 724–726 (2016).

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