The function and regulation of repetitive DNA, the 'dark matter' of the genome, is still only rudimentarily understood. Now a study investigating DNA replication of repetitive centromeric chromosome segments has started to expose a fascinating replication program that involves suppression of ATR signalling, in particular during replication stress.
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Tognetti, S., Speck, C. Replicating repetitive DNA. Nat Cell Biol 18, 593–594 (2016). https://doi.org/10.1038/ncb3367
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DOI: https://doi.org/10.1038/ncb3367