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Primary cilia mechanosensing triggers autophagy-regulated cell volume control

The primary cilium and the process of autophagy are thought to be in a functionally reciprocal relationship. In further support of this link, fluid flow sensing by the primary cilium is now shown to induce autophagy, which in turn regulates the volume of kidney epithelial cells.

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Figure 1: Regulation of the epithelial kidney cell volume is mediated by primary-cilium-dependent autophagy.

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Correspondence to Tassula Proikas-Cezanne.

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Takacs, Z., Proikas-Cezanne, T. Primary cilia mechanosensing triggers autophagy-regulated cell volume control. Nat Cell Biol 18, 591–592 (2016). https://doi.org/10.1038/ncb3366

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