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PGC1α drives a metabolic block on prostate cancer progression

Metabolic rewiring is essential for cancer cell survival. PGC1α, a transcriptional co-activator that is downregulated in prostate cancer, is now shown to control prostate cancer metabolism by activating an oxidative metabolic program that prevents tumour growth and metastatic dissemination.

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Figure 1: A PGC1α–ERRα gene expression signature induces a catabolic state in prostate cancer that decreases metastasis.


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Correspondence to Christian M. Metallo.

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Wallace, M., Metallo, C. PGC1α drives a metabolic block on prostate cancer progression. Nat Cell Biol 18, 589–590 (2016).

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