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Directing lipid transport at membrane contact sites

Contact sites between the endoplasmic reticulum and the plasma membrane mediate receptor signalling. How this function is controlled physically and functionally is poorly understood. Extended synaptotagmins are now shown to shuttle the lipid metabolite diacylglycerol from the plasma membrane to the endoplasmic reticulum in receptor-stimulated cells.

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Figure 1: E-Syts promote the transport of DAG at ER–PM contact sites.


  1. Hu, J., Prinz, W. A. & Rapoport, T. A. Cell 147, 1226–1231 (2011).

    CAS  Article  Google Scholar 

  2. Vance, J. E. Traffic 16, 1–18 (2015).

    CAS  Article  Google Scholar 

  3. Phillips, M. J. & Voeltz, G. K. Nat. Rev. Mol. Cell Biol. 17, 69–82 (2016).

    CAS  Article  Google Scholar 

  4. Henne, W. M., Liou, J. & Emr, S. D. Curr. Opin. Cell Biol. 35, 123–130 (2015).

    CAS  Article  Google Scholar 

  5. Carrasco, S. & Meyer, T. Annu. Rev. Biochem. 80, 973–1000 (2011).

    CAS  Article  Google Scholar 

  6. Berridge, M. J. Biochim. Biophys. Acta 1793, 933–940 (2009).

    CAS  Article  Google Scholar 

  7. Saheki, Y. et al. Nat. Cell Biol. 18, 504–515 (2016).

    CAS  Article  Google Scholar 

  8. Giordano, F. et al. Cell 153, 1494–1509 (2013).

    CAS  Article  Google Scholar 

  9. Sudhof, T. C. Neuron 80, 675–690 (2013).

    CAS  Article  Google Scholar 

  10. Idevall-Hagren, O., Lu, A., Xie, B. & De Camilli, P. EMBO J. 34, 2291–2305 (2015).

    CAS  Article  Google Scholar 

  11. Schauder, C. M. et al. Nature 510, 552–555 (2014).

    CAS  Article  Google Scholar 

  12. Alva, V. & Lupas, A. N. Biochim Biophys Acta (2016).

  13. Kim, Y. J., Guzman-Hernandez, M. L., Wisniewski, E. & Balla, T. Dev. Cell 33, 549–561 (2015).

    CAS  Article  Google Scholar 

  14. Manford, A. G., Stefan, C. J., Yuan, H. L., Macgurn, J. A. & Emr, S. D. Dev Cell 23, 1129–1140 (2012).

    CAS  Article  Google Scholar 

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Correspondence to Michael Krauβ or Volker Haucke.

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Krauβ, M., Haucke, V. Directing lipid transport at membrane contact sites. Nat Cell Biol 18, 461–463 (2016).

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