Contact sites between the endoplasmic reticulum and the plasma membrane mediate receptor signalling. How this function is controlled physically and functionally is poorly understood. Extended synaptotagmins are now shown to shuttle the lipid metabolite diacylglycerol from the plasma membrane to the endoplasmic reticulum in receptor-stimulated cells.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Hu, J., Prinz, W. A. & Rapoport, T. A. Cell 147, 1226–1231 (2011).
Vance, J. E. Traffic 16, 1–18 (2015).
Phillips, M. J. & Voeltz, G. K. Nat. Rev. Mol. Cell Biol. 17, 69–82 (2016).
Henne, W. M., Liou, J. & Emr, S. D. Curr. Opin. Cell Biol. 35, 123–130 (2015).
Carrasco, S. & Meyer, T. Annu. Rev. Biochem. 80, 973–1000 (2011).
Berridge, M. J. Biochim. Biophys. Acta 1793, 933–940 (2009).
Saheki, Y. et al. Nat. Cell Biol. 18, 504–515 (2016).
Giordano, F. et al. Cell 153, 1494–1509 (2013).
Sudhof, T. C. Neuron 80, 675–690 (2013).
Idevall-Hagren, O., Lu, A., Xie, B. & De Camilli, P. EMBO J. 34, 2291–2305 (2015).
Schauder, C. M. et al. Nature 510, 552–555 (2014).
Alva, V. & Lupas, A. N. Biochim Biophys Acta http://dx.doi.org/10.1016/j.bbalip.2016.01.016 (2016).
Kim, Y. J., Guzman-Hernandez, M. L., Wisniewski, E. & Balla, T. Dev. Cell 33, 549–561 (2015).
Manford, A. G., Stefan, C. J., Yuan, H. L., Macgurn, J. A. & Emr, S. D. Dev Cell 23, 1129–1140 (2012).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Krauβ, M., Haucke, V. Directing lipid transport at membrane contact sites. Nat Cell Biol 18, 461–463 (2016). https://doi.org/10.1038/ncb3345
Published:
Issue Date:
DOI: https://doi.org/10.1038/ncb3345
