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Blood, blebs and lumen expansion

A powerful combination of cell labelling, genetic tools and rapid imaging techniques in vivo has now led to a high-resolution description of lumen formation during angiogenesis in zebrafish. The study reveals a haemodynamic-force-driven and myosin-II-dependent cellular mechanism (termed inverse membrane blebbing) as the basis for lumen expansion in unicellular and multicellular angiogenic sprouts.

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Figure 1: Haemodynamic forces and inverse membrane blebbing promote lumen formation in angiogenic sprouts.


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Correspondence to Erez Raz.

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Reichman-Fried, M., Raz, E. Blood, blebs and lumen expansion. Nat Cell Biol 18, 366–367 (2016).

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