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Multiple cilia suppress tumour formation

Nature Cell Biology volume 18, pages 368–369 (2016)Cite this article

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Primary cilia are cellular structures that have important functions in development and disease. The suppression of multiciliate differentiation of choroid plexus precursors, and maintenance of a single primary cilium by Notch1, is now shown to be involved in choroid plexus tumour formation.

Primary cilia perform crucial roles in organogenesis and vertebrate development. These ancient structures have been shown to be essential for cell polarity, migration and fate determination, and represent key sites for the integration of signal transduction pathways1. Primary cilia are partially isolated from the rest of the cell by a transition zone at their base, and use specialized intraflagellar transport systems to maintain distinct distributions of sensory and signal transduction proteins2. A prominent signalling cascade exploiting this unique structure is Sonic Hedgehog (Shh), which requires a primary cilium for localization and high-level activation of the critical Smoothened (Smo) receptor and other pathway components3. Among their many functions, primary cilia have an essential role in the regulation of brain stem cells and the development of the nervous system4.

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Figure 1: Notch1 activation suppresses multiciliate differentiation in choroid plexus epithelium.

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  1. Departments of Pathology, Charles Eberhart is at the Johns Hopkins University School of Medicine, Ophthalmology and Oncology, Baltimore, Maryland 21205, USA,

    Charles Eberhart

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  1. Charles Eberhart
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Correspondence to Charles Eberhart.

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Eberhart, C. Multiple cilia suppress tumour formation. Nat Cell Biol 18, 368–369 (2016). https://doi.org/10.1038/ncb3331

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