Broken ends of a budding yeast chromosome exhibit increased mobility, presumably to facilitate repair by recombination. A new study reports that increased mobility reflects the untethering of the broken chromosome, triggered by a DNA damage response that phosphorylates the Cep3 kinetochore protein and weakens the association between the centromere and the spindle pole body.
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Nakajima, Y., Haber, J. Chromosomes at loose ends. Nat Cell Biol 18, 257–259 (2016). https://doi.org/10.1038/ncb3321
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DOI: https://doi.org/10.1038/ncb3321