How distinct Arp2/3 complex variants regulate actin filament assembly

The heptameric Arp2/3 complex generates branched actin filament networks that drive lamellipodium protrusion, vesicle trafficking and pathogen motility. Distinct variants of the Arp2/3 complex are now shown to have different roles in tuning actin assembly and disassembly, in concert with the prominent actin regulators cortactin and coronin.

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Figure 1: Arp2/3 complex composition determines the efficiency of actin-based vaccinia virus motility.

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Correspondence to Klemens Rottner.

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Rottner, K., Stradal, T. How distinct Arp2/3 complex variants regulate actin filament assembly. Nat Cell Biol 18, 1–3 (2016). https://doi.org/10.1038/ncb3293

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