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Metabolic exit from naive pluripotency

Nature Cell Biology volume 17, pages 1519–1521 (2015)Cite this article

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Spatiotemporally distinct pluripotent states captured in vitro provide an accessible way of modelling early human development. An intricate interplay between the metabolome and histone modifications is now shown to drive the metabolic switch from human naive to primed pluripotency, one of the earliest steps of embryogenesis.

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Figure 1: A metabolic switch for the naive-to-primed state transition in human embryonic stem cells (hESCs).

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Authors and Affiliations

  1. Jun Wu and Juan Carlos Izpisua Belmonte are at the Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, California 92037, USA,

    Jun Wu & Juan Carlos Izpisua Belmonte

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  1. Jun Wu
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  2. Juan Carlos Izpisua Belmonte
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Correspondence to Juan Carlos Izpisua Belmonte.

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Wu, J., Belmonte, J. Metabolic exit from naive pluripotency. Nat Cell Biol 17, 1519–1521 (2015). https://doi.org/10.1038/ncb3269

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