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STIMATE reveals a STIM1 transitional state

Nature Cell Biology volume 17, pages 1232–1234 (2015)Cite this article

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Decreases in endoplasmic reticulum calcium content are sensed by resident STIM proteins, which can activate plasma membrane Orai channels to facilitate Ca2+ entry. The role of STIMATE, a previously unknown component of the store-operated calcium entry complex, has now been identified and defined.

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Figure 1: Regulation of STIM1 activation by STIMATE.
Figure 2: STIM–Orai interaction is regulated by the actions and interactions of multiple adaptors.

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Authors and Affiliations

  1. Robert Hooper and Jonathan Soboloff are at the Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA,

    Robert Hooper & Jonathan Soboloff

  2. J.S. is also in the Department of Medical Genetics & Molecular Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA,

    Jonathan Soboloff

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  1. Robert Hooper
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  2. Jonathan Soboloff
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Correspondence to Jonathan Soboloff.

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Hooper, R., Soboloff, J. STIMATE reveals a STIM1 transitional state. Nat Cell Biol 17, 1232–1234 (2015). https://doi.org/10.1038/ncb3245

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