Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Fumarate in DNA repair

A new study suggests that fumarase, a metabolic enzyme normally associated with ATP production in mitochondria, is recruited to sites of DNA damage where it produces fumarate to inhibit histone demethylation and promote repair of DNA double strand breaks.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Fumarase interacts with H2A.Z to promote NHEJ

References

  1. Jiang, Y. et al. Nat. Cell Biol. 17, 1158–1168 (2015).

    Article  CAS  Google Scholar 

  2. Ciccia, A. & Elledge, S. J. Mol. Cell 40, 179–204 (2010).

    Article  CAS  Google Scholar 

  3. Wang, C. & Lees-Miller, S. P. Int. J. Radiat. Oncol. Biol. Phys. 86, 440–449 (2013).

    Article  CAS  Google Scholar 

  4. Dynan, W. S. & Yoo, S. Nucleic Acids Res. 26, 1551–1559 (1998).

    Article  CAS  Google Scholar 

  5. Xu, Y. et al. Mol. Cell 48, 723–733 (2012).

    Article  CAS  Google Scholar 

  6. Fnu, S. et al. Proc. Natl Acad. Sci. USA 108, 540–545 (2011).

    Article  CAS  Google Scholar 

  7. Yogev, O. et al. PLoS Biol. 8, e1000328 (2010).

    Article  Google Scholar 

  8. Xiao, M. et al. Genes Dev. 26, 1326–1338 (2012).

    Article  CAS  Google Scholar 

  9. Gibson, B. A. & Kraus, W. L. Mol. Cell 41, 497–499 (2011).

    Article  CAS  Google Scholar 

  10. Krell, D. et al. Future Oncol. 9, 1923–1935 (2013).

    Article  CAS  Google Scholar 

  11. Cairncross, J. G. et al. J. Clin. Oncol. 32, 783–790 (2014).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Susan P. Lees-Miller.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lees-Miller, S. Fumarate in DNA repair. Nat Cell Biol 17, 1096–1097 (2015). https://doi.org/10.1038/ncb3232

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncb3232

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing