Supplementary Figure 6 : Cooperation between taxol and inhibitors of mitotic survival pathways.

From: AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest

Supplementary Figure 6

Cell death was quantified by scoring To-Pro3 levels by high-throughput microscopy after the addition of the indicated compounds in the presence or absence of taxol in MDA-MB-468, EVSA-T or MCF7 breast cancer cells (left panels) or BJ-TERT-2 and RPE non-transformed cells (right panels). Pink columns indicate significant cooperation when compared to both single inhibitors (black dotted comparisons) and taxol (red dotted comparisons). The number of cells analyzed (n) is indicated in each condition. Data are mean ± SEM (n = 6 independent experiments). , P < 0.001; Student’s t-test, and represent one out of 6 independent experiments. Source data can be found in Supplementary Table 4.