Figure 8 : Working model for peroxisomal ATM signalling to the TSC signalling node to repress mTORC1, phosphorylation of PEX5 to induce ubiquitylation by PEX2/10/12 E3 ligase, and recognition of Ub–PEX5 by p62 to induce pexophagy in response to ROS.

From: ATM functions at the peroxisome to induce pexophagy in response to ROS

Figure 8