Integrin-based focal adhesions integrate biochemical and biomechanical signals from the extracellular matrix and the actin cytoskeleton. The combination of three-dimensional super-resolution imaging and loss- or gain-of-function protein mutants now links the nanoscale dynamic localization of proteins to their activation and function within focal adhesions.
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Giannone, G. Super-resolution links vinculin localization to function in focal adhesions. Nat Cell Biol 17, 845–847 (2015). https://doi.org/10.1038/ncb3196
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DOI: https://doi.org/10.1038/ncb3196
