Gut healing: haemocytes aid via Sax and Tkv jazzes it down

Control of stem cell activity is essential for accurate regeneration. Pathogen- or chemical-induced intestinal damage is now shown to recruit haemocytes expressing bone morphogenetic protein signals that stimulate proliferation of intestinal stem cells and subsequently induce their quiescence, in conjunction with muscle-derived bone morphogenetic proteins. A temporal switch in expression of Type I receptors enables this two-phase response.

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Figure 1: Temporal control of regeneration by differential Dpp signalling to intestinal stem cells.

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Correspondence to Daniela Drummond-Barbosa.

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Weaver, L., Drummond-Barbosa, D. Gut healing: haemocytes aid via Sax and Tkv jazzes it down. Nat Cell Biol 17, 707–709 (2015). https://doi.org/10.1038/ncb3178

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