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Gut healing: haemocytes aid via Sax and Tkv jazzes it down

Nature Cell Biology volume 17, pages 707–709 (2015)Cite this article

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Control of stem cell activity is essential for accurate regeneration. Pathogen- or chemical-induced intestinal damage is now shown to recruit haemocytes expressing bone morphogenetic protein signals that stimulate proliferation of intestinal stem cells and subsequently induce their quiescence, in conjunction with muscle-derived bone morphogenetic proteins. A temporal switch in expression of Type I receptors enables this two-phase response.

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Figure 1: Temporal control of regeneration by differential Dpp signalling to intestinal stem cells.

References

  1. Buchon, N., Broderick, N. A., Kuraishi, T. & Lemaitre, B. BMC Biol. 8, 152 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Ayyaz, A., Li, H. & Jasper, H. Nat. Cell Biol. 17, 736–748 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Lucchetta, E. M. & Ohlstein, B. Wiley Interdiscip. Rev. Dev. Biol. 1, 781–788 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Guo, Z., Driver, I. & Ohlstein, B. J. Cell Biol. 201, 945–961 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Li, H., Qi, Y. & Jasper, H. Cell Rep. 4, 10–18 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Tian, A. & Jiang, J. eLife 3, e01857 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Zhou, J. et al. Dev. Biol. 399, 189–203 (2015).

    Article  CAS  PubMed  Google Scholar 

  8. Harris, R. E. & Ashe, H. L. EMBO Rep. 12, 519–526 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Moustakas, A. & Heldin, C. H. Development 136, 3699–3714 (2009).

    Article  CAS  PubMed  Google Scholar 

  10. Bangi, E. & Wharton, K. Development 133, 3295–3303 (2006).

    Article  CAS  PubMed  Google Scholar 

  11. Aurora, A. B. & Olson, E. N. Cell Stem Cell 15, 14–25 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Ables, E. T., Laws, K. M. & Drummond-Barbosa, D. Wiley Interdiscip. Rev. Dev. Biol. 1, 657–674 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Biteau, B., Hochmuth, C. E. & Jasper, H. Cell Stem Cell 9, 402–411 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Villeda, S. A. et al. Nature 477, 90–94 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Gopinath, S. D. & Rando, T. A. Aging Cell 7, 590–598 (2008).

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Lesley N. Weaver and Daniela Drummond-Barbosa are in the Department of Biochemistry and Molecular Biology and the Division of Reproductive Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, 21205, USA,

    Lesley N. Weaver & Daniela Drummond-Barbosa

  2. Daniela Drummond-Barbosa is also in the Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, Maryland, 21205, USA,

    Daniela Drummond-Barbosa

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  1. Lesley N. Weaver
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  2. Daniela Drummond-Barbosa
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Correspondence to Daniela Drummond-Barbosa.

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Weaver, L., Drummond-Barbosa, D. Gut healing: haemocytes aid via Sax and Tkv jazzes it down. Nat Cell Biol 17, 707–709 (2015). https://doi.org/10.1038/ncb3178

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