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Control of ciliation in embryogenesis

The protrusion of cilia into extracellular space provides cells with sensors of localized environmental cues that include fluid flow, mechanical force and important growth factors such as Hedgehog. Live imaging has now captured the initial appearance of cilia during embryogenesis, and defined lineage-specific determinants that restrict extra-embryonal ciliogenesis.

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Figure 1: Primary cilia expression depends on embryonic stage and cell lineage.
Figure 2: NEDD9 and AURKA activation of HDAC6 inhibits the primary cilium on XEN cells.

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Correspondence to Erica A. Golemis.

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Nikonova, A., Golemis, E. Control of ciliation in embryogenesis. Nat Cell Biol 17, 109–111 (2015). https://doi.org/10.1038/ncb3103

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