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A niche role for periostin and macrophages in glioblastoma

Nature Cell Biology volume 17, pages 107109 (2015) | Download Citation

Macrophages facilitate tumour progression, but it is unclear whether this capability is influenced by tumour-initiating cells. Glioblastoma stem cells are now shown to secrete periostin, a matrix protein that recruits protumoral macrophages and enhances glioblastoma progression in mice.

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Author information

Affiliations

  1. Mario Leonardo Squadrito and Michele De Palma are at the Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland

    • Mario Leonardo Squadrito
    •  & Michele De Palma

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Michele De Palma.

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DOI

https://doi.org/10.1038/ncb3095

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