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Ironing out VPS34 inhibition

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The class III phosphoinositide 3-kinase VPS34 regulates autophagosome formation. Three groups have developed VPS34 inhibitors and shown their utility in investigating and defining autophagic processes.

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Figure 1: Functions of VPS34 in autophagy and endocytosis.
Figure 2: NCOA4 and selective degradation of ferritin complexes.

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Correspondence to Jayanta Debnath.

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Marsh, T., Debnath, J. Ironing out VPS34 inhibition. Nat Cell Biol 17, 1–3 (2015). https://doi.org/10.1038/ncb3089

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