The class III phosphoinositide 3-kinase VPS34 regulates autophagosome formation. Three groups have developed VPS34 inhibitors and shown their utility in investigating and defining autophagic processes.
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References
Murrow, L. & Debnath, J. Annu. Rev. Pathol. 8, 105–137 (2013).
Schu, P. et al. Science 260, 88–91 (1993).
Volina, S. et al. EMBO J. 14, 3339–3348 (1995).
Vanhausebroeck, B., Guillermet-Guibert, J., Graupera, M. & Bilanges, B. Nat. Rev. Mol. Cell Biol. 11, 329–341 (2010).
Lemmon, M. Nat. Rev. Mol. Cell Biol. 9, 99–111 (2008).
Dowdle, W. et al. Nat. Cell Biol. 16, 1069–1079 (2014).
Ronan, B. et al. Nat. Chem. Biol. 10, 1013–1019 (2014).
Bago, R. et al. Biochem. J. 463, 413–427 (2014).
Rogov, V., Dotsch, V. & Kirkin, V. Mol. Cell. 53, 167–178 (2014).
Mancias, J. et al. Nature. 509, 105–109 (2014).
Boada-Romero, E. et al. EMBO J. 32, 566–582 (2013).
Yeh, S. & Chang, C. Proc. Natl Acad. Sci. USA 93, 5517–5521 (1996).
Asano, T. et al. Mol. Cell Biol. 31, 2040–2052 (2011).
Kishi-Itakura, C., Koyama-Honda, I., Itakura, E. & Mizushima, N. J. Cell Sci. 127, 4089–4102 (2014).
Pantopoulos, K., Porwal, S., Tartakoff, A. & Devireddy, L. Biochemistry. 51, 5705–5724 (2012).
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Marsh, T., Debnath, J. Ironing out VPS34 inhibition. Nat Cell Biol 17, 1–3 (2015). https://doi.org/10.1038/ncb3089
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DOI: https://doi.org/10.1038/ncb3089
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