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Solving the centriole disengagement puzzle

Nature Cell Biology volume 17, pages 3–5 (2015)Cite this article

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The microcephaly protein, Cep215, contributes to the engagement of duplicated centrioles in interphase. Now two distinct pools of Cep215 at centrosomes are identified, one bound to Cep68 and the other to pericentrin. Plk1-mediated degradation of Cep68 and separase-mediated cleavage of pericentrin release both pools of Cep215, thereby promoting centriole disengagement.

Maintaining orderly progression through the centrosome cycle is key to human health. Centrosomes are the major site of microtubule nucleation and contribute to cell polarity, migration and division. As a result, defects in the centrosome cycle can cause many human diseases, with cancer as perhaps the most obvious associated pathology. The majority of tumour cells have excess centrosomes, promoting genome instability and invasion1,2. Furthermore, centrosome defects are implicated in a range of inherited genetic diseases, including ciliopathy syndromes and brain developmental disorders3.

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Figure 1: Cep215 has a dual role in centrosome cohesion.

References

  1. Ganem, N. J., Godinho, S. A. & Pellman, D. Nature 460, 278–282 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Godinho, S. A. et al. Nature 510, 167–171 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Marthiens, V. et al. Nat. Cell Biol. 15, 731–740 (2013).

    Article  CAS  PubMed  Google Scholar 

  4. Mardin, B. R. & Schiebel, E. J. Cell Biol. 197, 11–18 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Graser, S., Stierhof, Y. D. & Nigg, E. A. J. Cell Sci. 120, 4321–4331 (2007).

    Article  CAS  PubMed  Google Scholar 

  6. Pagan, J. et al. Nat. Cell Biol. 17, 31–43 (2015).

    Article  CAS  PubMed  Google Scholar 

  7. Mennella, V., Agard, D. A., Huang, B. & Pelletier, L. Trends Cell Biol. 24, 188–197 (2014).

    Article  CAS  PubMed  Google Scholar 

  8. Lee, K. & Rhee, K. Cell Cycle 11, 2476–2485 (2012).

    Article  CAS  PubMed  Google Scholar 

  9. Matsuo, K. et al. Curr. Biol. 22, 915–921 (2012).

    Article  CAS  PubMed  Google Scholar 

  10. Conduit, P. T. et al. eLife 3, e03399 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  11. Firat-Karalar, E. N., Rauniyar, N., Yates, J. R. III & Stearns, T. Curr. Biol. 24, 664–670 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Barrera, J. A. et al. Dev. Cell 18, 913–926 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Cabral, G., Sans, S. S., Cowan, C. R. & Dammermann, A. Curr. Biol. 23, 1380–1387 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Tsou, M. F. et al. Dev. Cell 17, 344–354 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Lee, K. & Rhee, K. J. Cell Biol. 195, 1093–1101 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Conduit, P. T. et al. Dev. Cell 28, 659–669 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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  1. Department of Biochemistry, Andrew M. Fry is at the University of Leicester, Leicester LE1 9HN, UK,

    Andrew M. Fry

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Correspondence to Andrew M. Fry.

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Fry, A. Solving the centriole disengagement puzzle. Nat Cell Biol 17, 3–5 (2015). https://doi.org/10.1038/ncb3087

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