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Hippo signalling directs intestinal fate

Nature Cell Biology volume 17, pages 56 (2015) | Download Citation

Hippo signalling has been associated with many important tissue functions including the regulation of organ size. In the intestinal epithelium differing functions have been proposed for the effectors of Hippo signalling, YAP and TAZ1. These are now shown to have a dual role in the intestinal epithelium, regulating both stem cell proliferation and differentiation along a specific secretory lineage.

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Author information

Affiliations

  1. Marie Le Bouteiller and Kim B. Jensen are at BRIC – Biotech Research and Innovation Centre, University of Copenhagen, Ole Maaløes Vej 5, DK-2200 Copenhagen N, Denmark

    • Marie Le Bouteiller
    •  & Kim B. Jensen

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Kim B. Jensen.

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DOI

https://doi.org/10.1038/ncb3086

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