Cyclin C surprises in tumour suppression

Despite the importance of cyclins and cyclin-dependent kinases (Cdks) in the control of cell division, the physiological role of many of these regulators remains unknown. Cyclin C and its associated kinases Cdk3, Cdk8 and Cdk19 are now shown to function as tumour suppressors in haematopoietic malignancies by inhibiting the Notch1 pathway.

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Figure 1: Cellular function of cyclin C and related kinases.
Figure 2: Alteration of cyclin C and its associated kinases in human cancer.

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Correspondence to Marianna Trakala.

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Trakala, M., Malumbres, M. Cyclin C surprises in tumour suppression. Nat Cell Biol 16, 1031–1033 (2014). https://doi.org/10.1038/ncb3055

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