Ovarian epithelium regeneration by Lgr5+ cells

Lgr5, a marker of stem cells in many organs, is found expressed in cells scattered through the ovarian epithelium that expand to repair and regenerate the damaged ovarian surface after each ovulation. Lgr5-positive stem cells in the ovary and the fimbria of the oviduct may be critical cells of origin for ovarian cancer.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Signals in fetal stages may establish the Lgr5+ population in the OSE and oviduct.

References

  1. 1

    Ng, A. et al. Nat. Cell Biol. 16, 745–757 (2014).

  2. 2

    Zheng, W. et al. Hum. Mol. Genet. 23, 920–928 (2014).

  3. 3

    Mork, L. et al. Biol. Reprod. 86, 37 (2012).

  4. 4

    Szotek, P. P. et al. Proc. Natl Acad. Sci. USA 105, 12469–12473 (2008).

  5. 5

    Flesken-Nikitin, A. et al. Nature 495, 241–245 (2013).

  6. 6

    Gamwell, L. F., Collins, O. & Vanderhyden, B. C. Biol. Reprod. 87, 80 (2012).

  7. 7

    Minkina, A. et al. Dev. Cell 29, 511–520 (2014).

  8. 8

    Parma, P. et al. Nat. Genet. 38, 1304–1309 (2006).

  9. 9

    Maatouk, D. M. et al. Dev. Biol. 383, 295–306 (2013).

  10. 10

    Kim, Y. et al. PLoS Biol. 4, e187 (2006).

  11. 11

    Usongo, M. & Farookhi, R. BMC Dev. Biol. 12, 17 (2012).

  12. 12

    Paik, D. Y. et al. Stem Cells 30, 2487–2497 (2012).

  13. 13

    Wang, Y. et al. PLoS ONE 7, e40691 (2012).

  14. 14

    Kim, J. et al. Proc. Natl Acad. Sci. USA 109, 3921–3929 (2012).

  15. 15

    Auersperg, N. Front. Biosci. (Schol. Ed.) 5, 709–719 (2013).

Download references

Author information

Correspondence to Blanche Capel.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Capel, B. Ovarian epithelium regeneration by Lgr5+ cells. Nat Cell Biol 16, 743–744 (2014) doi:10.1038/ncb3020

Download citation

Further reading